The fastest way to stop a toothache at night may be to open the pulp, cut and drain, take painkillers, etc. It is recommended to go to the hospital for timely consultation. 1. The most likely cause of a toothache at night is an acute attack of acute pulpitis, which is mainly caused by the pressure in the pulp cavity, and the fastest way to stop the pain is to open the pulp cavity in time. If it is purulent pulpitis, etc. can also contain cold water to ease the pain, if the effect is not great, it is recommended to consult a doctor in time. 2. If you have an apical abscess at night, you can cut and drain out the pus to relieve the pressure and stop the pain. 3. If it is inconvenient to consult a doctor at night, you can take painkillers or apply cold compresses, such as acetaminophen and ibuprofen, etc. It is recommended that you follow your doctor’s instructions on how to use the medication. However, painkillers have limited therapeutic effects, it is recommended to consult a doctor in a timely manner, self-medication is risky.