Cholera belongs to category A infectious disease, patients will have diarrhea, vomiting and other symptoms, need to take timely medication. Cholera is caused by cholera enterotoxin group O1 or O139 Vibrio cholerae infection, mainly through contact with feces and excreta contaminated food or water, cholera belongs to category A infectious disease in China. Generally, cholera patients will have diarrhea, feces in the form of rice slop, vomiting, sunken eye sockets, dry skin, decreased urine output, decreased blood pressure and other manifestations. Patients presenting with cholera need antibiotics such as ciprofloxacin, doxycycline, and levofloxacin under doctor’s supervision. For patients with dehydration symptoms, intravenous supplementation of glucose solution, sodium chloride solution and other fluid therapy is required as prescribed by the doctor. Cholera belongs to category A infectious diseases, it is recommended that patients need to seek medical treatment in time, and need to choose appropriate measures under the guidance of doctors to avoid delaying the condition. In addition, patients should avoid drinking unclean water and wash their hands before and after meals.