Clinically, if the monoplegia lesion is located in cortical or subcortical area, the monoplegia can be central, and if the lesion is located in the anterior horn of the spinal cord, anterior root, or peripheral nerves, the monoplegia is peripheral. For cerebral palsy disease, its symptoms are not only monoparesis, but also spastic hemiparesis, spastic diplegia, and non-involuntary movement type of cerebral palsy disease, these symptoms are based on the affected parts of the limbs and the nature of movement disorders, so in the clinic should pay attention to the differential diagnosis. Differential diagnosis of hemiplegia: 1. Hemiplegia: also called hemiplegia, refers to the motor disorder of one side of the upper and lower limbs, facial muscles and lower part of the tongue muscles, which is a common symptom of acute cerebrovascular disease. Although patients with mild hemiplegia can still move around, when they walk, they tend to flex their upper limbs and straighten their lower limbs, and the paralyzed lower limbs take one step and make half circle, this special walking posture is called hemiplegic gait. This special walking posture is called hemiplegic gait. Severe cases often become bedridden and lose their ability to live. According to the degree of hemiplegia, it can be categorized into mild paralysis, incomplete paralysis and total paralysis. Light paralysis: manifested as weakening of muscle strength, muscle strength at level 4-5, usually does not affect daily life, incomplete paralysis is heavier than light paralysis, the range is larger, muscle strength at level 2-4, total paralysis: muscle strength at level 0-1, paralyzed limbs are completely unable to move. 2, lower limb muscle paralysis: lower limb muscle paralysis is a symptom of spinal cord compression disorder. Quadriplegia: quadriplegia refers to the decrease or disappearance of random movements of the limbs. 4, peripheral paralysis of the upper limbs: peripheral paralysis is also known as lower motor neuron paralysis, or flaccid paralysis, flaccid paralysis. It is due to the spinal cord anterior horn cells and brain in the motor nerve nucleus, and its occurrence of fiber – spinal cord root, spinal nerve, cranial nerve damage produced by the paralysis. Peripheral paralysis of the upper limbs refers to the peripheral paralysis of the upper limbs at the site of onset. 5, peripheral nerve paralysis: common in amyotrophic lateral sclerosis, mononeuritis, polyneuritis, infection, poisoning. Vascular lesions tumor and systemic diseases. 6, muscle lesions and neuromuscular junction lesions resulting in paralysis: common in myasthenia gravis, polymyositis progressive muscular dystrophy, periodic paralysis. 7.Paraplegia：After spinal cord injury, the loss of sensation, movement and reflexes of both limbs below the injury plane and the loss of bladder and anal sphincter functions are a kind of disease. The complete loss of these functions is called complete paraplegia, and those with partial function are called incomplete paraplegia. In the early stage, the paraplegia is flaccid, and after about 3 to 4 weeks, it gradually turns into spastic paralysis. The cause of paraplegia is related to spinal cord trauma or its own lesions. Modern western medicine has no ideal method for this disease except for surgical treatment in the acute stage of spinal cord injury. It is one of the most important and difficult diseases to treat.