Sclerodactyly of the penis (also called Peyronie’s disease) was first reported in 1742 and often develops in middle-aged and older men. Patients have a bent and painful penis during erection, a weak erection distal to the penile sclerosis, and a severe deformity that interferes with sexual intercourse. When the penis is weak, there is no pain. On examination, fibrous nodules or cords of different sizes confined to the white membrane of the penile corpus cavernosum may be palpated in the corpora penis, without pressure pain, and the nodules are often located distal to the corpora penis. In patients with this condition, multiple nodules may be palpated, and in severe cases, calcification and ossification may be seen on radiographs. During the diagnosis, the patient needs to masturbate or inject vasoactive drugs to make the penis erect, and objectively determine the direction and degree of erectile curvature. High-resolution ultrasound and radiography of the penile area are also used to objectively determine the size of the plaque or calcification, the number of lesions, and to assess the efficacy of the treatment. Although the current understanding of Peyronie’s disease is unclear, the pathological changes are consistent with severe vasculitis. It is also the fact that research into the pathogenesis of the disorder is still unclear that has resulted in none of the current treatment outcomes for penile sclerosis being very satisfactory, and outcomes vary widely. Treatment methods can be divided into surgical and non-surgical treatments. The principle of treatment is to take local anti-inflammatory, pain relief and swelling, and to promote the softening or disappearance of the hard nodes. Only patients with severe curvature of the penis and difficulty in sexual life need to take surgical treatment. (A) non-surgical treatment 1, there is a controlled trial to confirm the role of local injection of collagenase for mild symptoms, can make the curvature reduced by about 10-15 °. Local injection of verapamil in the sclerotic plaque may also be effective, and it has been reported that the curvature can be improved in 60% of patients, but there is no controlled trial to confirm the conclusion. 2.At present, the drugs that have not proved to be effective include oral high-dose vitamins, ethylene estradiol, potassium para-aminobenzoate, potassium iodide, etc.; intramuscular injection of cortisone acetate 25mg plus procaine, and local interferon. 3.Physical therapy: including superficial X-ray irradiation, histamine iontophoresis, ultrasonic therapy, audio physiotherapy, etc. (ii) Surgery The purpose of surgical treatment is mainly to make the penis not bend when erect and to peel away the hard nodes. At present, the commonly used surgical methods include surgical node excision and prosthesis implantation, but the surgical effect is not ideal, and easy to recur after surgery.