Penile sclerosis is a lesion in which fibrous sclerosis occurs on the white membrane of the corpus cavernosum of the penis, mostly in young and middle-aged patients. The cause of the disease is still not clear. It is thought that minor injuries to the penis, such as surgery, riding injuries, small injuries caused by frequent sexual intercourse and excessive masturbation, systemic collagen diseases, atherosclerosis, diabetes, vitamin E deficiency, alcoholism, etc. may be related to the occurrence of the disease, and it is also thought that the occurrence of the disease may be related to certain genetic factors. Most patients have no conscious symptoms, but can be found unintentionally by feeling one or several striated or oval hard nodules or cord-like plaques on the dorsal side or root of the penis, with a texture like cartilage, and the volume can range from green beans to peanut me-like size. Most patients have no discomfort when the penis is flaccid and have localized swelling and pain when erect. Smaller nodules have no effect on erection, while larger nodules can affect the stretching of the white membrane on that side, causing the penis to bend to the affected side and, in severe cases, making penile penetration difficult and affecting sexual life. The lesions first appear in the loose connective tissue between the corpus cavernosum and the tunica albuginea, and the early lesions resemble vasculitis, followed by the formation of collagen fiber-based plaques on the adjacent cavernous septum and tunica albuginea, mostly on the dorsal side of the penis. Limited calcification and ossification are seen at the lesion site, but no ulceration or malignancy occurs. It does not invade the urethral corpus cavernosum, so difficulty in urination rarely occurs. The diagnosis is simple and the size of the nodule can be determined by ultrasound. How to prevent and treat? 1. There is no special treatment method. Oral administration of large amounts of vitamin E is considered to have a positive effect, and most patients have different degrees of improvement after taking the drug. 2.Potassium aminobenzoate can resist fibrosis and has certain efficacy. 3, local injection of drugs to inhibit the proliferation of connective tissue hydrocortisone acetate is effective in early lesions. 4, drug ionization therapy, steroids or histamine and other drugs, through direct current through the skin into the lesion area, relatively safe and less painful than the injection of drugs. 5.Ultrasonic therapy, heat transmission therapy or ultraviolet radiation can be used as auxiliary treatment to improve the symptoms. 6.High frequency physiotherapy can be used as a comprehensive treatment method. 7.Local radiation therapy can soften and absorb the hard nodes, there are reports of extracorporeal shock wave treatment of hard nodes, the efficacy needs to be further confirmed. 8.Surgical treatment: when the erection of the penis bending deformation for more than a year or plaque calcification, seriously affect the sex life, then surgical treatment is feasible to peel off the hard nodes, the purpose is mainly to make the penis straight, but the surgical effect of this disease is not good, the lesion is easy to recur after surgery. 9, Chinese medicine to dredge the liver and Qi, blood circulation and blood stasis, spleen and phlegm treatment, may have some effect. 10, life should try to avoid penile injury, abstain from excessive masturbation, advocate regular sex life to prevent the occurrence of penile micro-injury, to prevent the problem before it happens.