Lowly differentiated adenocarcinoma of the stomach can be treated with pentafluorouracil in combination with oxaliplatin.
Lowly differentiated adenocarcinoma of the stomach is relatively fast-growing, highly malignant, and often in an advanced stage when detected. Surgery and radiotherapy can be considered for treatment, but the treatment plan depends on the patient’s physical condition, and it is generally accepted clinically that chemotherapy is not very effective for hypofractionated adenocarcinoma.
The chemotherapy regimen can start with pentafluorouracil or can be combined with oxaliplatin at the same time, which has a good inhibitory effect in relieving the progressive phase of hypofractionated adenocarcinoma of the stomach. It is also necessary to adjust the medication at any time during chemotherapy according to the patient’s condition. If the patient has severe adverse reactions after the medication, it is also possible to change to another chemotherapy regimen. The patient may choose a chemotherapy agent other than an anthracycline and combine it with trastuzumab.
If the patient is in good health, it is appropriate to consider a trial of the chemotherapy drug for a period of time to observe the symptoms and continue if the effect is significantly reduced or controlled. If the effect is not good, you need to change to other chemotherapy drugs in time and pay attention to the liver and kidney function.