Recently, a new coronavirus variant, Omicron, has emerged in some countries and has been classified by the World Health Organization as a strain of “concern”, following Alpha, Beta, Gamma and Delta. Although not much is known about this variant virus and it is unclear whether a vaccine booster is useful against the vaccine, it is still recommended to get an aggressive booster vaccination and to take care of daily protection. Compared to the previous Delta strain, the Omicron strain carries an “extremely large” number of stinging protein mutations, and the diversity of these mutations may lead to increased viral infectivity and ability to evade vaccine immunity, but how harmful it is, how quickly it will spread, whether it will make the disease more severe, and how well the current vaccine protects against the Omicron variant is unknown at this time. However, there is a lack of sufficient data on the protective effect of the current vaccine against the Omicron variant, and studies are still underway. It is important to clarify that antibody levels decline over time after vaccination and can be significantly stimulated to rebound with a booster shot. Previous relevant studies have shown that not only do antibody levels increase after booster immunization, but the antibody spectrum also becomes broader and the ability to resist mutant strains is strengthened, meaning that better protection against mutant strains is achieved. Therefore, even though accurate data are not yet available, booster prophylaxis against Omicron may still be effective. It is recommended to actively vaccinate against Oncoron and to do booster shots when available, especially in elderly people, whose antibody levels are themselves significantly lower than those of young people after vaccination and will decrease even more significantly with time, and booster shots are very important to prevent Oncoron infection and to reduce the risk of serious illness and death. At the same time, it is still necessary to pay attention to daily protection, wear masks in indoor public places, public transportation and other places, and also wash hands regularly and ventilate the room well.