In normal people, long-term use of anticoagulants may lead to bleeding, gastrointestinal reactions, emotional problems, allergies and other hazards, as explained below. Long-term use of anticoagulants can induce the occurrence of thrombocytopenia, inhibit the function of coagulation factors, resulting in abnormal coagulation function. It is easy to cause bleeding in the skin and mucous membranes and other parts of the body, and it is not easy to stop bleeding. Severe cases may cause cerebral hemorrhage. Long-term chronic bleeding is also likely to cause anemia. Long-term use of anticoagulants may cause damage to the gastrointestinal mucosa, gastrointestinal mucosal ulcers, erosion, often accompanied by nausea, vomiting, abdominal pain, diarrhea and other gastrointestinal adverse reactions. Long-term oral anticoagulants such as warfarin may cause tension, anxiety, depression, agitation and other adverse emotions, especially in patients who have had bleeding. If patients are allergic to certain components in anticoagulants, it may cause allergic reactions, leading to the occurrence of skin rashes, neurologic edema, and even anaphylaxis. Therefore, patients who need to take oral anticoagulants should pay attention to the above side effects, especially bleeding, and need to follow the doctor’s instructions for regular review, and any abnormalities in a timely manner to seek medical attention for treatment.