Diagnostic points 1. Onset after 60 years of age. 2. Gradual onset and progressive development. 3, Clinical manifestations are based on memory impairment and personality changes and progressive generalized dementia. 4. Pneumoencephalography shows enlarged ventricles, diffuse brain sulcus widening or cystic enlargement, and CT examination shows brain atrophy. Symptomatic treatment 1, for insomnia, emotional agitation and anxiety, use anti-anxiety drugs such as Valium, Librium, Nitro Valium, Sulezade, etc. 2, mood depression, the use of tricyclic antidepressants, such as doxepin, nortriptyline, amitriptyline, etc. 3.For patients with excitement and delusion, methionine can be used, starting from 25-50mg daily dose, slowly increasing, effective treatment daily dose of 50-300mg. or Endorphin, daily dose of 4-30mg. trifluralin, daily dose of 2-20mg. 4, improve cognitive function, take drugs to promote brain metabolism, such as pyridoxine 400-800mg tid. pyrithione 0.1g acid tid. inosine 0.2g tid . Adenosine triphosphate 20-40mg tid, etc., and drugs to improve cerebral blood circulation, such as cipro 5mg tid. nimodipine 20 mg tid with and a lot of vitamins, etc.