Benzene and leukemia are not necessarily related, but may be a cause of leukemia. Benzene is a toxic chemical, and some of the triggers of leukemia may be due to environmental pollution or chemicals, but there is no necessary link between the two. Most children with leukemia onset may be exposed to a variety of toxic substances as a trigger, and other factors may need to be involved, such as genetic factors and genetic mutation factors. Children have weakened immune defenses and exposure to any toxic substance may cause mutations in their somatic cells or chromosomes, which may induce malignancy. Therefore, repeated stimulation by similar benzene or other chemical toxic substances including radioactive substances may cause immune deficiency in children and lead to the occurrence of malignant tumors, thus the two are an indirect relationship. For example, newly renovated houses may have a large amount of benzene residue, which may induce the development of childhood leukemia if occupied early. Similar precedents exist in the past, but from the perspective of epidemiological investigation, but there is no strict evidence to prove that excessive chemical elements, or toxic substances in newly renovated houses can directly cause the occurrence of leukemia, but may indirectly affect the immune function of children and indirectly cause the occurrence of leukemia.