The incidence of Crohn’s disease has a clear familial aggregation, usually significantly higher in first-degree relatives than in the general population, and has a certain genetic predisposition. Identical twins can develop the disease together with a prevalence of 6% to 16%, while the prevalence in dizygotic twins is only 0-5%. The disease also has racial differences, the incidence of Caucasians is high, the incidence of blacks and Asians is low, the incidence of whites is 3 times that of blacks, the incidence of Jews is 3 to 5 times that of non-Jews. 1. Does Crohn’s disease affect reproductive function? Young women with Crohn’s disease have somewhat reduced fertility for a variety of possible reasons, starting with the disease itself, which may lead to malnutrition, infection, complications surgery and reduced female endocrine function. Large abdomen . Surgery such as partial or complete colectomy, small bowel-rectal anastomosis or ileostomy may have some impact on pregnancy and fertility. Second, many women with Crohn’s disease often avoid pregnancy for subjective reasons. They are afraid of pregnancy, believing that it will recur, worsen the disease or affect the fetus. Moreover, these patients may prefer to use contraception for the condition or for psychological reasons. 2. Can Crohn’s disease affect the growth and development of children? Children with Crohn’s disease are often malnourished due to malabsorption, chronic intestinal blood loss caused by malnutrition, anemia and other complications, pediatric patients often due to impaired absorption of nutrients resulting in slow growth and development. 3.Does Crohn’s disease affect intelligence? There is no research that Crohn’s disease itself will directly affect the level of intelligence, but severe malnutrition in pediatric patients may affect intellectual development. 4. What Crohn’s disease-related medications can affect fertility? Currently, Crohn’s disease is not thought to significantly affect fertility (in both men and women), but men taking salazosulfapyridine and ralston may be at risk for reduced sperm count and activity. During pregnancy, induction of maintenance of Crohn’s disease remission is important and a key determinant of success in childbirth. Studies have found that the risk of preterm delivery and low birth weight babies is significantly higher when combined with active Crohn’s disease during pregnancy. Most of the drugs currently used for Crohn’s disease treatment can be taken during pregnancy, except for methotrexate and thalidomide, and TNF monoclonal antibodies (e.g., analogs) should also be discontinued before the sixth month of pregnancy.