Photodynamic therapy (5-aminoketovaleric acid, ALA-PDT) is one of the most successful methods used to treat warts in recent years. It uses a photosensitizer applied to the wart and the high-risk skin around the wart to produce a large amount of reactive oxygen species, which causes the death of the wart cells through cytotoxic effects, thus providing a therapeutic effect. 1, the treatment of the uncomfortable reaction to the light localized pins and needles pain is the most common discomfort, generally after 5-10 minutes will be self-relieved, no special treatment, but many first-time patients will continue to exist pain, burning pain, for obvious pain can be local topical lidocaine cream or lidocaine spray, or even to painkillers oral muscle injection. Preoperative communication and education should be done to dispel patients’ concerns and build up confidence. 2, the uncomfortable reaction after treatment photodynamic therapy will generally experience three stages of local performance: edema necrosis period, atrophy off period, recovery period. Within 2-3 days after treatment, patients may experience local redness and swelling, mild erosion, blood-like discharge, stinging pain in urine and other feelings, which are normal reactions, the heavier the reaction, the more certain the effect. As long as attention is paid to keeping the local area dry and clean, drinking more water, urinating more often, and using topical amikacin spray to prevent infection, it can generally be relieved on its own within 1 week. In addition, in the urethra, the vagina, the anus and other hidden parts of the tube cavity lesions, conventional therapy is more difficult to operate, photodynamic therapy is easy to repeatedly repeated treatment without causing scars, adhesions, stenosis and other side effects.