Clinical practice has proven that all patients with type 1 diabetes and some type 2 diabetes need to be treated with insulin. According to the needs of the disease, the dosage, dose and frequency of insulin use vary from one diabetic patient to another. Specifically, there are about eleven uses of insulin: 1. Once a day with medium-acting insulin: The duration of the effect of medium-acting insulin is about 12 hours, so generally diabetic patients need to inject twice a day. However, if the patient’s pancreatic islet function is less damaged, only the blood glucose after three meals during the day is higher, and fasting blood glucose at night without eating is better controlled, you can inject one medium-acting insulin before breakfast. On the contrary, if the patient’s blood glucose is well controlled during the day and only the fasting blood glucose is high, such as obese, over-eating at dinner or diabetic patients whose blood glucose is significantly elevated in the early morning, one injection of medium-acting insulin can be given before bedtime, and the dose of injection is calculated at 0.2 units per kilogram of body weight. Patients can inject medium-acting insulin before bedtime so that the peak of insulin action occurs just before breakfast. This is beneficial for patients to control early morning hyperglycemia. 2. One medium-acting insulin before bedtime and oral hypoglycemic drugs during the day: diabetic patients with overweight bodies are prone to gain weight after insulin injection. If the blood sugar of such patients is not too high, they can take three times of oral hypoglycemic drugs of biguanide during the day to lower sugar, lipid and weight, and then inject once more medium-acting insulin before going to bed to fight the early morning hyperglycemia caused by insulin resistance. 3.Two times a day with intermediate-acting insulin: This usage is suitable for patients with mildly elevated fasting and postprandial blood glucose. After using insulin in this way, if the patient’s fasting blood sugar is well controlled, but the postprandial blood sugar is still high, Novolin 30R can be used instead, injected twice a day. 4.Two times a day with Novolin 30R or 50R: This usage is suitable for most diabetic patients with fasting blood sugar and postprandial blood sugar elevation as the main symptoms. The preparation is human insulin, the advantages of which are: good absorption performance and strong action. Patients can increase or decrease the proportion of insulin R appropriately according to the postprandial blood glucose, and generally this preparation only needs to be injected twice a day. But it also has shortcomings, that is, the high blood sugar control after lunch is not good, so the high blood sugar after lunch patients in the use of Novolin, but also need to add an oral hypoglycemic drugs. 5, three times a day with Novolin 30R: If a day with two Novolin 30R after lunch high blood sugar control is not good, can also be used three times a day with Novolin 30R, some patients apply this method is conducive to three meals and night before and after the blood sugar control, fasting blood sugar can also be well controlled. 6.Three times a day with short-acting insulin: This usage is suitable for diabetic patients with high blood sugar and first-time insulin use, or those who have severe infection and have just had surgery. The advantages are: patients can adjust the amount of insulin according to the blood sugar before meals and the amount of food eaten, and patients are less likely to have hypoglycemia after using the drug; the disadvantage is: poor control of high blood sugar at night and early morning. 7. Short-acting insulin before breakfast and lunch, and Novolin 30R before dinner: This usage is suitable for those with poor glycemic control who use Novolin 30R twice a day. The advantages of this usage are: it can reduce the dosage of insulin, improve the efficacy and avoid hypoglycemia in patients. The use of short-acting insulin before breakfast and Chinese meal can control the blood sugar after two meals, and the use of Novolin 30R to control the blood sugar after dinner and at night is more in line with the physiological condition of human insulin secretion. 8. Use short-acting insulin before three meals and medium-acting insulin before bedtime: This usage is suitable for the elderly or diabetic patients with high labor intensity and irregular diet, or those with poor blood sugar control in the early morning who use short-acting insulin before breakfast and lunch and Novolin 30R before dinner. The use of short-acting insulin before three meals to control postprandial blood glucose and medium-acting insulin or long-acting genetically recombinant insulin (glargine insulin, detergent insulin) before bedtime can maintain patients’ basal insulin secretion at night, which is more in line with the human insulin secretion law and can effectively inhibit the conversion of glycogen into glucose in the liver and reduce the decomposition of fat, keeping patients’ blood glucose stable at night and not easy for patients to have Hypoglycemia. 9. 4 times a day with short-acting insulin: that is, insulin is injected before three meals and before bedtime. This usage is suitable for diabetic patients who are using insulin for the first time or have ketosis and cannot be hospitalized temporarily. However, the dose of insulin injected before bedtime should preferably not exceed 10 units. 10.Once a day insulin analogues glargine insulin (Lysine) or disulfiram (Norplan): glargine insulin and disulfiram have stable absorption properties, which can avoid hyperglycemia due to the use of traditional long-acting suspensions with unstable absorption properties, effectively control basal blood sugar and reduce the chance of hypoglycemia in patients. Injecting once a day with Elactin or Novalis and using fast-acting insulin Eugenol or Novalis before three meals can simulate the secretion of human physiological insulin, and its glucose-lowering effect can be comparable to insulin pump. 11, 6 times a day with short-acting insulin: This use is suitable for patients with type 1 diabetes with special needs. In the 2000 Sydney Olympics, American short-course swimmer Hall was the Olympic champion with six injections of insulin in one day.