Leukemia is the most common malignancy in childhood, but happily, with reasonable and standardized treatment, most childhood leukemias can be cured, especially acute lymphoblastic leukemia (which is the most common type of leukemia in children), and more than 80% of children can be cured. However, it is important to emphasize that the basis of “rational and standardized treatment” is accurate diagnostic typing at the time of initial diagnosis! This is the only way to guide the correct clinical risk grouping (standard, intermediate and high risk), to give a reasonable and standardized treatment plan, and to achieve the goal of curing leukemia as we mentioned earlier. So, what does the diagnostic staging at the initial diagnosis include? At a minimum, cytomorphological, immunological, cytogenetic and molecular biological examinations, i.e. MICM diagnostic staging, are required. Indeed, due to the limitations of cytogenetic and molecular biology techniques, MICM typing in China has so far been carried out only in some teaching hospitals in large cities, while the vast majority of local hospitals are only able to carry out morphological and some immunological examinations, so that childhood leukemia is not correctly diagnosed and risk grouped, which seriously affects the rational treatment of the disease and causes many unnecessary complications, relapses and even This has caused many unnecessary complications, relapses and even deaths, bringing irreparable serious harm and disharmony not only to the children themselves, but also to their families and society. In addition, even in hospitals that can carry out MICM typing in China, these four tests are not only time-consuming but also expensive. Therefore, we have been studying the diagnostic typing of childhood acute lymphatic leukemia with new genotyping methods in recent years, and have achieved preliminary results, achieving the same effect as MICM typing.