Late stage lung cancer is too painful to analyze what is the specific cause of pain. If there is obvious dyspnea and the cause of dyspnea is obstructive pneumonia, corresponding treatment can be done for obstructive pneumonia and the use of morphine can reduce dyspnea. If there is a large amount of pleural effusion or pericardial effusion, performing puncture and drainage of pleural effusion or pericardial effusion can completely relieve the patient’s pain. If there are obvious bone metastases, local radiotherapy and particle implantation can be added to the use of morphine and other analgesic drugs. You can also boldly try targeted drugs, especially with gene mutation, such as EGFR gene mutation, you can use gefitinib, erlotinib and other drugs. In conclusion, patients with advanced lung cancer should actively find out where the disease of suffering lies and take appropriate treatment measures.