Hyperandrogenemia Definition: An increase in circulating levels of androgens. Androgens include testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone sulfate and dehydroepiandrosterone. There are three sources of testosterone in the blood serum of women: the follicles of the ovary can secrete testosterone, accounting for about 1/4; testosterone secreted by the adrenal cortex also accounts for 1/4; and testosterone converted by extra-glandular androstenedione accounts for about 1/2. The reasons for the increase of androgens in the blood of women: 1, excessive secretion by the ovary or the adrenal cortex. 2, testosterone, estrogen, androstenedione, androstenedione. 2. Decrease in testosterone and estradiol-binding globulin, resulting in an increase in free testosterone. 3, peripheral transformation, such as pregnenolone by metabolism, can be converted into testosterone. Hyperandrogenemia causes female infertility etiology: mainly affects the female ovulation Increased androgens can be converted (mainly in adipose tissue) into estrogen, non-cyclic estrogen level increases, increased luteinizing hormone to gonadotropin-releasing hormone sensitivity, but also increased follicle stimulating hormone negative feedback sensitivity, as a result, luteinizing hormone level increases, follicle stimulating hormone is relatively low. The increased luteinizing hormone stimulates the follicular membrane cells to proliferate and synthesize excessive androgens, resulting in poor follicular development and infertility.