Clear cell sarcoma, also known as soft tissue malignant melanoma, is a rare soft tissue malignancy that accounts for about 1% of soft tissue sarcomas. This disease can be found in any age group, the peak age of incidence is 20~40 years old, slightly more women than men. The tumor grows slowly and occurs in the extremities, mostly in the lower extremities, especially in the ankle and knee. At present, surgical resection is still the main method, but its anatomical site often does not allow extensive surgical resection, and if the lesion is too large or the site is not suitable for extensive resection, elective amputation is often performed. Incomplete local excision leading to recurrence is the main reason for treatment failure. Recurrence or metastasis is common, and metastasis eventually occurs in more than 1/2 of patients, mostly in lymph nodes, lungs and bones. The clinical efficacy of postoperative radiotherapy and chemotherapy is poor. However, amputation is cruel to young patients and seriously affects their quality of life. For tumors with residual or recurrence after surgery, local cryopreservation or radioactive particle placement can be used to improve the local control rate of tumors. Combined biological therapy is expected to inhibit distant metastasis and thus improve patient survival.