Patients who have finished chemotherapy, if the chemotherapy is effective and the tumor is controlled, its consumption of nutrients and energy in the body is reduced. At this time, the patient is in better physical condition and has a better chance of recovery after surgery. However, some patients develop anemia after chemotherapy and need preoperative treatment to create the conditions for surgery. Overall, the majority of patients with osteosarcoma are able to have surgery after chemotherapy. If the patient’s disease is detected early and the tumor is small, the outcome will be more optimistic; if the disease is advanced and the tumor load is high, the outcome will be relatively poor. Meanwhile, chemotherapy will affect the hematopoietic cells of human body, therefore, blood should be drawn frequently for blood picture, biochemical and coagulation tests. The patient’s liver function and kidney function should be noted. If the patient has problems with liver function, it must be dealt with in time to prevent serious organic damage, i.e., causing changes in the structural form, function, and metabolism of cells, tissues, organs, etc. Finally, patients should also be observed for systemic conditions such as pulmonary metastases.