1.What is the current status of soft tissue sarcoma treatment? (1) Surgery: At present, surgery still plays an important role in the treatment of soft tissue sarcoma, but the local recurrence rate of simple surgical resection is high, and the local recurrence rate is 50% for simple wide resection, and up to 80% for local resection. Highly malignant soft tissue sarcoma is prone to distant metastases in the lung and other sites, and even with radical surgery, recurrence and metastasis can occur with poor prognosis. In order to obtain satisfactory tumor margins and reduce the recurrence rate, amputation or complete resection of the involved muscle groups is often required, which seriously affects the quality of life of patients. (2) Radiotherapy: It is an important tool to improve the local control rate of soft tissue sarcoma. Especially for highly malignant soft tissue sarcoma, postoperative radiotherapy can achieve the effect of reducing the recurrence rate. It can be divided into preoperative radiotherapy, postoperative radiotherapy, post-mounted radiotherapy (inter-tissue irradiation, brachytherapy) intraoperative electron beam radiotherapy, particle implantation, which can be used alone or in combination according to the patient’s condition, but there are still debates on the time, mode and complications of radiotherapy giving. (3) Chemotherapy: IFO and ADM are now widely used as first-line drugs for chemotherapy of soft tissue sarcoma, but the remission rate varies for different sarcomas. The main problems in China at present are: ① High recurrence rate after surgery. ②No effective chemotherapy drugs for most sarcomas. ③How to use radiotherapy correctly. ④The rehabilitation of limb function after surgery. 2.What is cryotherapy for soft tissue sarcoma? Cryoablation therapy is an important ablation technique. The cryoprobe is accurately inserted into the tumor tissue under CT or ultrasound guidance, and the argon-helium freezing system is activated and cooled to kill the tumor with ultra-low temperature. The basic principle of cryoablation is to rapidly chill the tumor tissue to below -160℃ and then re-temperature it, which can directly cause dehydration and rupture of cancer cells; or destroy the small blood vessels of tumor and cause hypoxia, resulting in the death of tumor cells. The advantages of cryoablation treatment are: (1) local destruction of tumor tissue, less impact on normal tissue, and maximum protection of limb function. (2) Less damage to normal tissues compared with surgery, and can be repeatedly performed. (3) Small trauma (the diameter of cryoprobe is about 2-4mm), quick recovery, and normal activities can be resumed the day after surgery. (4) No toxic side effects of radiotherapy and chemotherapy. (5) For small tumors can achieve the purpose of cure. (6) It can treat tumors that cannot be removed by surgery of adjacent important organs (such as large blood vessels, intestines, ureter). (7) For thoracic, abdominal and retroperitoneal soft tissue sarcomas, multiple open-chest and open-abdomen surgeries can be avoided, which obviously improves the quality of life of patients. (8) Local necrotic tumor tissue can stimulate the body’s immune system and improve the body’s anti-tumor immune function. (9) Freezing has synergistic effect with chemotherapy or radiotherapy. (10) For recurrent soft tissue sarcoma after surgery, cryotherapy can help to improve the local control rate. 3.What is the efficacy of cryotherapy for soft tissue sarcoma? Under the guidance of ultrasound or CT, the cryoprobe can be inserted accurately into the tumor tissue, and the efficacy of local treatment is sure. Meanwhile, for tumors in the abdominal cavity, chest cavity, retroperitoneum, head and neck are often inoperable due to their proximity to important organs, while cryotherapy is less traumatic and can reach the conventional surgical exclusion zone and give active treatment to tumors in special areas. 4.Can other treatments be combined with cryotherapy for soft tissue sarcoma? Cryoablation is an effective treatment for soft tissue sarcoma, but due to the deep location of some soft tissue sarcomas, their size is too large or they are close to important organs, so cryoablation is not complete. Minimally invasive treatments such as intra-tissue radioactive particle implantation and local perfusion chemotherapy in the tumor supply artery can be combined with cryoablation to further control the remaining tumor tissue.