Osteosarcoma mostly occurs in adolescence when the bones are growing and developing vigorously, and is highly malignant and complicated to treat. Once diagnosed with osteosarcoma, chemotherapy is very crucial in addition to surgery. However, because most hospitals do not have bone tumor specialists and corresponding nursing teams, they cannot administer regular and reasonable chemotherapy, so many patients lose a good chance of chemotherapy. The correct chemotherapy method should be 1-2 courses of high-dose chemotherapy immediately after diagnosis, and surgery one week after the completion of chemotherapy, and histopathological examination of tumor after surgery to determine the necrosis rate of tumor, and then determine whether the preoperative chemotherapy is effective according to the necrosis rate of tumor, and then insist on 3-4 courses of chemotherapy after the removal of stitches in two weeks after surgery to achieve satisfactory results. At present, the commonly used chemotherapy drugs are methotrexate, adriamycin, cisplatin and isocyclophosphamide.