The treatment of malignant bone tumors needs to be handled by bone tumor specialists. In recent years, it has been found that the different treatment methods for bone tumors make a big difference in 5-year survival rate! First of all, no selective biopsy: for most malignant bone tumors, the existing imaging means are sufficient for clear diagnosis, while blind biopsy will destroy the pseudo-envelope of the tumor, contaminate local tissues and cause tumor cells to break through the envelope, just like a murderer escaping from prison! Thus, it brings difficulties to limb preservation! For the very few who have difficulty in diagnosis, non-biopsy must be operated within a week! Secondly, radiotherapy and chemotherapy of most tumors are adjuvant, surgery should be the main focus, not to put the cart before the horse! Because the biological behavior of tumor cells has not been clarified, and the existence of drug resistance genes, making chemotherapy is not uniformly effective for the same tumor, even for the same tumor patients, drug resistance can occur at different times! Then again, only microwave in situ inactivation and reconstruction can preserve joint function!