Is neoadjuvant chemotherapy prone to nausea, vomiting and other reactions? What should I do if I have these reactions? Neoadjuvant chemotherapy is prone to nausea, vomiting, hair loss and other reactions, which are caused by chemotherapy drugs. These reactions are caused by chemotherapy drugs. Since chemotherapy drugs must be used due to the need of treatment, these reactions cannot be treated for the cause, but only for the symptoms. That is, antiemetic drugs are given after the appearance of vomiting, and the daily consumption of energy and electrolytes is replenished. What should I do when mouth ulcers appear in neoadjuvant chemotherapy? When mouth ulcers appear, it is necessary to distinguish the cause of the ulcers. If oral ulcers appear during chemotherapy, i.e., when chemotherapy drugs are not used up, they are considered to be related to nutritional deficiency and vitamin deficiency, and are simple ulcers. However, if the mouth ulcers are caused by chemotherapy drugs, they need to be treated. For example, patients applying methotrexate need to be given calcium folinic acid for relief and alkalinization of urine at the same time; patients applying cisplatin, isocyclophosphamide or doxorubicin are more likely to be given supportive treatment, etc. What is the cause of electrolyte abnormalities, fever and neutropenia during chemotherapy? Electrolyte abnormalities are caused by the loss of electrolytes due to nausea and vomiting during chemotherapy, and the absorption of electrolytes due to edema in the mucous membrane of the digestive tract caused by chemotherapy drugs, i.e., the body has more electrolytes out than in. Electrolyte abnormalities are a common symptom of chemotherapy side effects and only require intravenous electrolyte supplementation. However, if electrolytes are severely abnormal, it may be life-threatening. As for the phenomenon of neutropenia, it is mainly due to the decrease in hematopoietic cells of the three bone marrow lines caused by chemotherapy drugs, and the decrease in white blood cells and neutrophils, which in turn leads to protective fever, suggesting that the body’s ability to fight infection is reduced. Lack of sufficient neutrophils may lead to bacterial sepsis in severe cases. For fever and neutropenia, we need to give triple cephalosporins or stronger anti-inflammatory drugs (Mepin, Tylenol, etc.) for infection prevention treatment along with chemotherapeutic drugs for relief.