Whether lung cancer metastasis using chemotherapy is effective or not is mainly closely related to the cytological typing of lung cancer. If the metastasis occurs in squamous lung cancer, the effect of chemotherapy is relatively poor, and the patient’s survival period is about one year. If metastasis occurs in lung adenocarcinoma, the effect of chemotherapy alone is also less satisfactory, and the patient’s survival is about one year. If lung cancer gene targeting test indicates genetic mutation, targeted drug therapy can be given and then combined with chemotherapy, which can effectively prolong the survival period and quality of life of patients. Therefore, the effectiveness of lung cancer metastasis using chemotherapy is mainly related to the basic condition of the patient and whether it is adenocarcinoma, or squamous carcinoma. The effect on squamous carcinoma is relatively poor, while adenocarcinoma with sensitive gene mutation, combined with gene targeting drugs, can more effectively prolong patients’ survival.