Lumbar 4.5 vertebral endplate inflammation is a sterile inflammation of the cartilage of the endplates due to degeneration, previous trauma, and other causes. In the lumbar spine the vertebrae are connected to each other by intervertebral discs, and the structure that connects the vertebrae to the discs is called the endplate, which is also a layer of fibrocartilaginous tissue. As the lumbar vertebrae degenerate with age or due to previous lumbar trauma, the vertebral endplates accumulate damage during activities, where inflammatory cells gather and aseptic inflammation occurs, resulting in the formation of endlaminitis. Clinical symptoms of lumbar endplates are mostly limited to lumbar pain around the diseased segment, and the pain is aggravated by activities. Signal changes in the endplates can be visualized through lumbar MRI. When patients experience lumbar discomfort, they should actively seek medical attention to avoid delaying their condition.