Hemangiomas are not associated with trauma. Current research is unclear as to the etiology and pathogenesis of hemangiomas, which are mainly thought to be related to angiogenesis and abnormal proliferation of blood vessels, with more recent studies demonstrating that the latter plays a major role. Hemangioma may be caused by a variety of factors, including dysfunction between angiogenic and inhibitory factors, as well as mutations in oncogenes, inactivation of oncogenes and changes in the endothelium of the local microenvironment, including changes in the levels of many hormones, but many suspected predisposing factors have been identified in studies, including long-term exposure of the mother to leather, plastics, paints and daily exposure to chemical fertilizers and pesticides , are risk factors for infantile hemangioma, but the factors for adult hemangioma are not well defined at this time.