1.Related to family history There is a positive family history of mental illness, and those with a positive family history have a relatively poor prognosis. The prognosis is worst for mono type, followed by adolescent type, and relatively better for nervous type and paranoid type. The earlier the age of onset, the worse the prognosis is. On the contrary, the later the age of onset, the better the prognosis is. For example, the prognosis of patients with late-onset schizophrenia is relatively good, because their psychological structure and personality development have been relatively stable, and their ability to resist external influences is relatively strong, so their personality can remain relatively intact after the disease, and there is almost no decline in social function. 4, and traits related to positive symptoms relative to negative symptoms, the more positive symptoms, the better the prognosis; conversely, the more negative symptoms, the worse the prognosis 5, and the discovery, diagnosis, and intervention time related to early detection, early diagnosis, early intervention is a more important factor affecting the prognosis. Most diseases should adhere to the “three early principles”, schizophrenia is no exception, generally speaking, schizophrenia early positive symptoms are prominent, with the progression of the disease, the negative symptoms will become more and more, the effect is worse and worse, so it is recommended that the family to learn more about psychiatry, early detection of the problem, and early diagnosis, clear diagnosis, timely and appropriate intervention. Clearly diagnosed and given appropriate treatment in time, so that the condition can be controlled as early as possible to avoid delays. In addition, the first treatment must be adequate, with sufficient dosage and course of treatment. Each relapse will aggravate the condition, and the treatment time will be relatively increased. The increased number of relapses is also one of the negative factors affecting poor prognosis. 6, with the sensitivity of the drug in the treatment, the more sensitive to the drug, the earlier the better the efficacy, so that the disease is well controlled, the prognosis is relatively good . 7, with the season from the clinical point of view of the disease every year in the spring and / or fall easy to fluctuate, so patients and their families every year in the corresponding seasonal changes should pay attention to the observation of the condition, if necessary, by the specialist to make appropriate adjustments to the drug. 8, related to the law of the disease itself The individual differences of schizophrenic patients are quite large, and the stabilization level of each person’s condition is not always maintained at the same level, but is dynamic like waves, some people may fluctuate once a year, and some may fluctuate once every three years or so. This requires patients and their families to pay attention to summarize the pattern of change of their own disease, every easy to fluctuate in the stage of the disease should pay attention to observation, shorten the time of follow-up, and keep in touch with the specialist, so as to achieve early detection and early intervention. 9, and physical comorbidities The more physical comorbidities, the worse the prognosis, combined with serious physical disease, because physical disease itself will have a negative impact on the patient’s body and mind, thus affecting the condition of schizophrenia; in addition, drug interactions can affect the efficacy. 10, related to the way of medication Safeguard the use of medication is a very key factor in preventing relapse. Because the cause of schizophrenia is not completely clear, drug therapy is only symptomatic treatment, control symptoms, prevent relapse, delay the progress of the disease. Therefore, patients with good compliance, active cooperation with the treatment, regular review, to ensure the smooth progress of the whole treatment, the prognosis is relatively good. 11, related to the support of family support (better economic foundation, stable family relations, moderate emotional expression), social support (stable work and interpersonal relationships) and other related support (the corresponding national policy support, the recognition of society as a whole, tolerance, acceptance) the more complete the system, the more in place, the patient can get more support, so that the patient has a good sense of belonging, is conducive to the mental rehabilitation, so that they can better return to society. 12.Related to their own influencing factors, sound personality foundation, a good attitude towards the disease and an optimistic and positive attitude towards people and things, rich life experience and coping skills to deal with setbacks, and building a relatively stable interpersonal relationship environment are all conducive to the stabilization of the disease. 13, related to the application of drugs The application of the second generation of new antipsychotic drugs, for schizophrenia, negative symptoms, positive symptoms, cognitive impairment are effective, with little side effects, is conducive to the patient’s mental recovery, so as to better return to society.