Palmoplantar hyperhidrosis is mainly characterized by sweaty palms and soles of the feet. In mild cases, the palms are only moist, while in severe cases, the palms can produce beads of sweat visible to the naked eye. In severe cases, the palms of the hands may produce beads of sweat that are visible to the naked eye. Because the skin of the hand is often moist and soaked, the palm of the hand molts significantly and is often accompanied by dermatitis. In winter, cold and wet extremities can lead to frostbite and skin ulceration. Patients often have sweaty palms since childhood or adolescence, which affects daily life and work. The sweaty hands tend to affect the dexterity of the hands and interfere with manual operations. Patients avoid shaking hands with others, which affects interpersonal communication and creates avoidance and anxiety. The survey showed that 50% of the patients felt a lack of self-confidence and 38% of the patients had a sense of frustration. The number of patients with a sense of depression also reaches about 20%. Palmoplantar hyperhidrosis is sympathetic hyperexcitability, but often causes distress at school, work or socially and is treated by a doctor. Most of the time, the palms of the hands are wet, and chronically wet hands often cause easy peeling, which is an eyesore. Young people of school age often have a lot of sweaty hands that make their exam papers wet and affect their exams, often before the papers are even written. Teenagers are afraid to hold hands with others, and even shaking hands is a problem. In severe cases, eczema dermatitis may even appear on the palms of their hands. In adulthood, this can cause inconvenience in work and social activities. Patients with hyperhidrosis often have a combination of foot sweating, and the sweat is usually odorless, unlike fox odor. In contrast, patients with fox odor (underarm sweating and odor) are more genetically related, mainly because of the developed sebaceous glands in the armpits, which have a higher incidence than hand sweating and cause more common problems. For example, there are always yellow stains on clothes that cannot be washed away, and they do not dare to wear sleeveless tops, and most importantly, they have a psychological burden and fear when approaching people. The palms of the hands, soles and armpits are always sweaty, wet and cold, sometimes in the form of drops of sweat, and even more serious when emotionally stressed. Often when writing to get the paper wet, typing to drip wet keyboard, more afraid to shake hands with others. Patients with hand-foot hyperhidrosis may also experience sweating and sweaty palms in crowded situations, during meetings and presentations, when meeting strangers, when meeting acquaintances and leaders, when they are nervous and excited, when exercising, when meeting the opposite sex, and when talking about sensitive topics.