1, changes in the skin: skin thinning, de-pinning, hyperpigmentation, darkening, itching, serious cases may have running water, ulcers, etc. 2, vascular changes: the most common is thrombotic superficial phlebitis, manifested as the original varicose blood vessels become hard, red and painful; some patients can induce deep vein thrombosis in the lower limbs, leading to more serious consequences. 3, vascular rupture bleeding, can be induced by ulcers, trauma or spontaneous rupture of small veins causing acute bleeding.