It is difficult to judge which one is more serious when comparing hepatitis B major triple positive and minor triple positive alone, and it needs to be combined with liver function, the presence of cirrhosis and liver cancer and other indicators. Hepatitis B Major Triple Positive is relatively active in terms of viral replication. Major triple positive and minor triple positive are two different types of hepatitis B. Major triple positive refers to hepatitis B virus infection, hepatitis B surface antigen, hepatitis B E antigen positive and core antibody, active viral replication in the body, and often relatively high viral load. Minor triple positive refers to positive hepatitis B surface antigen, hepatitis B E antibody and core antibody, with relatively inactive viral replication. Judging the severity of hepatitis mainly depends on whether the liver function is damaged and whether there are complications such as cirrhosis and liver cancer. Both major and minor triple positive may cause abnormal liver function, cirrhosis and liver cancer. Therefore, once the hepatitis B pentameter is found to be triple positive or triple positive, it is necessary to consult the doctor in time and standardize the treatment under the doctor’s guidance.