What are the manifestations of immune infertility in women? Immune infertility is a disease that has a great impact on couples who want to have children, and it accounts for about 10-30% of infertility patients. And it is a disease that both men and women can suffer from. So, what are the manifestations of female immune infertility? About 10-20% of the infertility patients are immune infertility. Immune infertility is generally divided into three categories: alloimmune, local immune and autoimmune. In general, women themselves do not produce immune reactions, and only about 15% to 18% of female infertility patients have anti-sperm antibodies in their bodies. This is usually due to endometrial damage during menstruation or endometritis or anal intercourse, resulting in sperm and its antigenic material easily entering the bloodstream and triggering an anti-sperm immune response in women. In some infertile women, the cervical mucosa and endometrium contain lymph-like cells that produce immunoglobulins G and A. The cervical mucus contains immunoglobulins G, A and M that are resistant to sperm, so the cervix and female reproductive tract have local immune effects against sperm. The overflow of female eggs, reproductive tract secretions and hormones from the reproductive tract into her own surrounding tissues also causes an immune response that produces corresponding antibody substances in the body, which affects follicle maturation and ovulation. In addition, antibodies against gonadotropic hormones and antibodies against gonadotropic hormone receptors in women can cause premature ovarian failure and ovarian amenorrhea. Endometriosis can produce catabolites during the menstrual cycle, which are eliminated by the macrophage system and stimulate antibody production resulting in autoimmunity.