Common side effects Allergic reactions are often characterized by skin eczema, urticaria or asthma, but also erythema multiforme-like drug rash. Highly allergic people, often in the process of injection, sudden agitation, loss of consciousness, lips and lips cyanosis, followed by respiratory and cardiac arrest. Drug overdose poisoning is often seen in children overdose or misuse, more than the maximum therapeutic dose (6mg / Kg / times), the early manifestations of nausea, vomiting, restlessness, and unconscious movements, thirst, dehydration and low fever; later may appear vomiting blood, delirium, convulsions, stupor, high fever and collapse, but also manifested as epileptic-like grand mal seizures. Death may occur due to medullary depression. The causes of aminophylline toxic side effects are related to the wide variation in individual dosing. Aminophylline clearance is slower in women than in men, in the elderly than in young adults, and obesity, liver disease, heart failure, chronic obstructive pulmonary disease, hypoxemia, acidosis, and high-carbohydrate diets all influence common toxic side effects. Allergic reactions are mostly manifested as skin eczema, urticaria or with asthma, there are also polymorphic erythema-like drug rash. Highly allergic people, often in the injection process, sudden agitation, loss of consciousness, lips and lips cyanosis, followed by respiratory arrest. Drug overdose poisoning is often seen in children overdose or misuse, more than the maximum therapeutic dose (6mg / Kg / times), the early manifestations of nausea, vomiting, restlessness, and unconscious movements, thirst, dehydration and low fever; later may appear vomiting blood, delirium, convulsions, stupor, high fever and collapse, but also manifested as epileptic-like grand mal seizures. Death may occur due to medullary depression. The causes of aminophylline toxic side effects are related to the wide variation in individual dosing. Aminophylline clearance rate, women slower than men, the elderly slower than young adults, obesity, liver disease, heart failure, chronic obstructive pulmonary disease, hypoxemia, acidosis and high-carbohydrate diet, are to affect the metabolism of aminophylline, so that its half-life is prolonged, according to the conventional dose of long-term application, can also cause poisoning. In addition, improper compounding is also the cause of toxic side effects of aminophylline. Retard theophylline metabolism of drugs such as erythromycin, spiramycin, H2 receptor antagonists, these drugs have reduced theophylline clearance, prolonging the half-life of the role of these drugs and aminophylline and easy to occur poisoning. Too fast injection rate can also cause aminophylline toxicity. The exact cause of toxicity of static injection of therapeutic doses is still unknown, and it is thought to be related to the speed of injection, so it is called “speed shock”. Metabolism, so that its half-life is prolonged, according to the regular dose of long-term application, can also cause poisoning. In addition, improper compounding is also the cause of toxic side effects of aminophylline. The drugs that delay theophylline metabolism include erythromycin, spiramycin, H2 receptor antagonists, etc. These drugs have the effect of reducing theophylline clearance and prolonging the half-life, and these drugs and aminophylline are easy to be poisoned when used in conjunction with aminophylline. Too fast injection rate can also cause aminophylline toxicity. The exact cause of static injection of therapeutic doses of toxicity is still unknown, and most of them are thought to be related to the injection speed, so there is a “speed shock”. Allergic reactions are often manifested as skin eczema, urticaria or with asthma, there are also erythema multiforme-like drug rash. Highly allergic, often in the process of injection, sudden agitation, loss of consciousness, lips and lips cyanosis, followed by respiratory arrest. Drug overdose poisoning is often seen in children overdose or misuse, more than the maximum therapeutic dose (6mg / Kg / times), the early manifestations of nausea, vomiting, restlessness, and unconscious movements, thirst, dehydration and low fever; later may appear vomiting blood, delirium, convulsions, stupor, high fever and collapse, but also manifested as epileptic-like grand mal seizures. Death may occur due to medullary depression. The causes of aminophylline toxic side effects are related to the wide variation in individual dosing. Aminophylline clearance rate, women slower than men, the elderly slower than young adults, obesity, liver disease, heart failure, chronic obstructive pulmonary disease, hypoxemia, acidosis and high-carbohydrate diet, are to affect the metabolism of aminophylline, so that its half-life is prolonged, according to the conventional dose of long-term application, can also cause poisoning. In addition, improper compounding is also the cause of toxic side effects of aminophylline. Retard theophylline metabolism of drugs such as erythromycin, spiramycin, H2 receptor antagonists, these drugs have reduced theophylline clearance, prolonging the half-life of the role of these drugs and aminophylline and easy to occur poisoning. Too fast injection rate can also cause aminophylline toxicity. The exact cause of static injection of therapeutic doses of toxicity is still unknown, mostly thought to be related to the speed of injection, so there is a “speed of shock”. As a bronchial antispasmodic agent has been used for half a century, at present, is still an important drug for the treatment of bronchial asthma. Intravenous injection of aminophylline asthma fast, efficacy, commonly used in the clinic, but the safety range is small, the therapeutic index is narrow, the rate of elimination of the body of individual variability is large, if not used properly, often easy to cause serious toxic side effects, and even life-threatening.