(I) Indications 1. newly discovered or gradually enlarged isolated lung nodules or masses with unknown diagnosis, especially those suspected to be lung cancer; 2. mediastinal masses with unknown diagnosis and hilar masses with negative fibreoptic bronchoscopy biopsy results, in order to clarify the pathologic diagnosis; 3. focal or multiple lung solid lesions or abscesses with unknown strains of infections; 4. tumors that cannot be operated on in order to clarify the cell types so as to formulate reasonable chemotherapy or radiotherapy plans, or to test the sensitivity of tumor cells to chemotherapy or radiotherapy; 5. pleural and chest wall and rib lesions that are difficult to be identified. 4. inoperable tumors, in order to define the cell type so as to formulate a reasonable chemotherapy or radiotherapy plan, or to test the sensitivity of tumor cells to chemotherapy or radiotherapy; 5. pleural, chest wall and rib lesions that are difficult to characterize. （Contraindications 1. severe cardiac, pulmonary, hepatic and renal insufficiency; 2. hemorrhagic and coagulation dysfunction, i.e., bleeding tendency; 3. cardiac pacemaker device; 4. metal foreign body near the puncture site; 5. the lesion examined may be pulmonary arteriovenous fistula or encapsulated disease; 6. the patient is unable to cooperate with the patient, or is unable to maintain a constant puncture position, or is unable to hold his/her breath. Typical case Female patient, 44 years old, with left-sided chest pain for one month and cough for one week. A Chest CT showed a space-occupying lesion in the left lung with clear borders and adhesions to the adjacent pleura; B and C MR-guided percutaneous biopsy showed that the tip of the puncture needle was located inside the lesion on transverse and oblique coronal scans, and low-differentiated squamous cell carcinoma was confirmed pathologically after accurate excision of the lesion tissue.