Postoperative recurrence is the most common cause of treatment failure in patients with NSCLC, and Taiwanese scholars Hung, Jung-Jyh conducted a study aimed at exploring the prognostic factors of patients who survived postoperative recurrence (PRS) of lung adenocarcinoma. (Journal of Thoracic Oncology, 2015, 10 (9):1328C1336) The study included 179 patients with postoperative recurrence of lung adenocarcinoma who attended Taipei Veterans General Hospital from 2004-2010, and retrospectively analyzed the prognostic, and predictive roles of the patients’ clinicopathological characteristics on PRS. There were 25 patients with local recurrence (15.4%), 56 patients with distant metastasis (34.6%), and 81 patients with local recurrence + distant metastasis (50.0%); 2-year and 5-year PRS were 65.2% and 29.8%, respectively; and the most common metastatic organs were the contralateral lungs (39.1%), the brain (33.5%), and the bone (31.3%). Multivariate analysis showed that micropapillary/solid-predominant tumors (HR = 2.615; 95% CI 1.395-4.901; P = 0.003 compared with vesicular/papillary-predominant tumors) had a shorter PRS in patients who did not receive treatment after recurrence (P < 0.001). However, for patients treated after recurrence, micropapillary/solid-predominant tumors (vs. vesicular/papillary tumors HR = 2.570; 95% CI 1.357-4.865; P = 0.004) were significant predictors of poor patient PRS. Surgical treatment after recurrence was expected to be a significant predictor of better PRS (p = 0.067). The study concluded that micropapillary/solid-dominant lung adenocarcinoma was a significant predictor of poor PRS prognosis compared with alveolar/papillary lung adenocarcinoma.