Some women experience urinary discomfort as soon as they are nervous and tired at work, with symptoms such as frequent urination, urgent urination, poor urination, discomfort in the lower abdomen and lumbosacral area and even difficulty in urination, urine loss and urinary incontinence. It is painful to go to the toilet constantly during the day and to urinate 7 to 8 times at night. Since women also experience frequent, urgent and painful urination when they have urinary tract infections, they are misdiagnosed by doctors as having acute UTIs. However, the patient is given antibiotics, but the effect is always missing. In fact, this condition is medically known as female urethral syndrome. Urethral syndrome is common in young and middle-aged women. Patients exhibit varying degrees of urinary frequency, urinary urgency, dyspareunia, lower abdominal and lumbosacral discomfort and other symptoms similar to urinary tract infections, but the urine routine examination is normal, or only a small number of red and white blood cells, negative urine culture, X-ray, ultrasound and cystoscopy without the presence of organic lesions of the bladder urethra. The cause and pathogenesis of urethral syndrome remain unknown. Urinary tract infection, urine holding, fatigue, childbirth, menstruation, sexual life, mental stress and anxiety are often predisposing factors. Recent urodynamic studies have found that patients have bladder and urethral dysfunction such as unstable bladder and increased urethral pressure. It is now believed that urethral syndrome is related to the underdevelopment or degeneration of the central nervous control function of urination, which causes increased sensitivity and hyperfunction of the central nervous system under the action of triggering factors. Many patients often have urinary tract infections first, and after improving with anti-infection treatment, the disease is triggered by factors such as holding urine and exertion after a period of time. In severe cases, the disease may develop into difficulty in urination or incontinence. Some patients have urinary frequency, urinary urgency, urine loss and incontinence since childhood, which can continue into adulthood, and the symptoms may also gradually worsen due to having children, leading a sexual life and gynecological diseases. Due to stressful work or unpleasant encounters in life, mental tension, anxiety, suspiciousness, introversion and nervousness also have an impact on the disease. Since the disease is not a urinary tract infection, anti-infective treatment is often ineffective. There is also a lack of particularly effective methods because the etiology is not clear. Bladder training, administration of drugs that affect bladder and urethral function (e.g., bladderling, Harlequin, Schenectady, etc.), hypnotherapy, urethral dilation, and endourethral incision are not effective. Patients often suffer from a long, lingering and recurrent course of the disease. In view of the pathogenesis of urethral syndrome, and according to the role of acupuncture in regulating the activity of the urinary center and correcting the dysfunction of the bladder and urethra, we have used acupuncture to treat female urethral syndrome for more than 10 years and achieved good clinical results. Generally, after an average of 21 treatments, 92.6% of patients with symptoms improved by ≥25%. Among them, 83.3% of patients with ≥50% improvement of symptoms and 44.4% of patients with complete disappearance of symptoms (clinical cure or 100% improvement of symptoms). Since its clinical application, this therapy has been welcomed by the patients.