High-grade papillary uroepithelial carcinoma should, in principle, be treated surgically. For high-grade papillary uroepithelial carcinoma of the renal pelvis, a full-length ureteral resection of the kidney should be performed. For high-grade papillary uroepithelial carcinoma of the ureter, full-length nephroureteral resection as well as partial bladder resection should also be performed. In the case of high-grade papillary uroepithelial carcinoma of the bladder, total cystectomy with a substitute bladder should be performed. Transurethral bladder tumor electrosurgery can also be chosen. After electrosurgery, bladder irrigation chemotherapy should be given in time and regular review should be done to observe whether the tumor has recurred. If there is recurrence again, total cystectomy is recommended.