High-grade intraepithelial lesions, which need to be considered precancerous, are of higher grade indicating lower malignancy, referring to the degree of cell differentiation. Highly differentiated is the least malignant, moderately differentiated is the second most malignant, lowly differentiated is more malignant, and undifferentiated is highly malignant. When high-grade intraepithelial lesions appear, the lesions are generally more limited, and gynecological diseases mostly occur in the cervix. Local surgical treatment is done promptly, such as choosing laser cryosurgery or cervical conization. If there are nearby lymph node metastases, the surgical area needs to be expanded, regional lymph node dissection is done, and in severe cases, the cervix or uterus needs to be removed. After surgery, appropriate drug chemotherapy is given and dynamic review is paid attention to, early detection and better treatment effect.