The basic symptom of leukoaraiosis is recurrent mouth ulcers, more than three times a year. Other major symptoms include pubic ulcers, various inflammatory eye diseases, various rashes, arthritis, and damage to the nervous and cardiovascular systems. In addition, some patients who experience injections and infusions may develop red spots at the puncture site that do not heal for several days. As can be seen, leukoaraiosis is a disease that can involve multiple systems throughout the body and can present with a variety of clinical manifestations. In some patients, the manifestations of each system appear only after a longer period of time. Specifically, the following: 1, oral cavity. Associated with the oral cavity is the appearance of oral ulcers, which manifest as recurrent episodes and can be located in the pharynx, tonsils, soft palate, and inside the mouth.2, Genital ulcers. Genital ulcers are possible, and about 75% of patients develop genital ulcers with lesions basically similar to oral ulcers.3, Ocular lesions. About 50% of patients have ocular lesions, which manifest as blurred vision, reduced vision, and foreign body sensation.4, Skin lesions. There are some patients with skin lesions of various kinds, with erythema nodosum being the most common; 5, joint damage. The joint lesions of leukoarthrosis are not specific; 6, his neurological damage and gastrointestinal damage appear less often and are not specific; 7, cardiovascular disease, the most frequent main symptoms are heart attack and or cerebrovascular disease in young people; etc.