Hemolytic disease is a hemolytic anemia caused by increased destruction of red blood cells, while the ability of the bone marrow to compensate for hematopoiesis cannot keep up with the rate of destruction. The following is a description of the disease concept, causes, clinical manifestations and treatment. 1. Hemolytic disease, also known as hemolytic anemia, refers to the shortening of the life span of red blood cells and the increase in destruction, which exceeds the ability of the bone marrow to compensate for hematopoiesis, resulting in a decrease in hemoglobin, leading to anemia in the body. It can be seen in patients of any age. 2. Common causes include intrinsic red blood cell defects, such as red blood cell membrane defects, red blood cell enzyme defects and other hereditary diseases; and extrinsic red blood cell factors, such as autoimmune hemolysis, disseminated intravascular coagulation, and severe infections. 3. Chronic hemolysis is often characterized by anemia, jaundice, splenomegaly, etc. Acute hemolysis may be manifested by causing chills, fever, headache, etc., and in severe cases, acute renal failure and peripheral circulatory failure may occur. 4. Treatment includes treating the cause of the disease (e.g. autoimmune hemolysis can be treated with glucocorticoids such as prednisone), blood transfusion, splenectomy, etc. The specific diagnosis and treatment should be directed by a physician. Specific diagnosis and treatment should be carried out under the guidance of physicians.