The prevention of purine stones (mainly 2,8-dihydroxyadenine stones and xanthine stones) should be based on a low purine diet; allopurinol inhibits xanthine oxidase, which reduces the excretion of 2,8-dihydroxyadenine, thus preventing the occurrence of stones. Theoretically, alkalinization of urine can promote the dissolution of 2,8-dihydroxyadenine stones. However, it is extremely difficult to raise the urine pH above 9.0 clinically through drugs. Therefore, the practical application of alkalinized urine is not of great value.