[Abstract] Objective To retrospectively analyze the clinical effects of interventional treatment of intermediate and advanced lung cancer, followed by surgical resection after perfusion. Methods The Seldinger technique was used to treat lung cancer with transbronchial artery perfusion of anticancer drugs, and the data of 68 lung cancer patients who could be followed up and recorded were collected. Results Clinical symptoms were significantly improved, and X-ray radiographs and CT scan review showed that the lesions were significantly reduced or disappeared. Conclusion Case selection, stage of bronchopulmonary cancer, distribution of blood supply, and drug selection are the direct keys to determine the remarkable efficacy of interventional treatment, and the comprehensive treatment method of combined with perfusion or post-perfusion surgical resection can significantly alleviate the disease, improve the quality of survival, and increase the survival time. [Keywords] Bronchial lung cancer; interventional therapy; medium and long-term efficacy Because most of the middle and advanced lung cancers have lost the opportunity of surgery, arterial interventional therapy is widely used in clinical practice, and the author has obtained relatively satisfactory results by using this method, and some patients have obtained the opportunity of secondary surgical radical treatment, which has significantly improved the survival quality. It is reported as follows. 1. Data and methods 1.1 General data In this group, there were 68 cases, 46 males and 22 females; age ranged from 41 to 73 years old, with an average of 59 years old. The clinical symptoms were mainly cough, blood in sputum, chest tightness, chest pain, shortness of breath, and cervical and facial swelling. Imaging examinations were performed in all cases. It was pathologically confirmed that there were 31 cases of squamous carcinoma, 13 cases of adenocarcinoma, 5 cases of undifferentiated carcinoma, and the remaining 19 cases that could be identified by combining X-ray, CT and bronchoscopy. 1.2 Methods A 5.0F Cobra type catheter was selected by Seldinger method via femoral artery cannulation, and the bronchial artery, subclavian artery, and internal mammary artery were selected according to the drugs, and continuous angiography was performed with a Japanese Shimadzu 1000mA angiography machine to observe the branching, distribution, and staining concentration of the tumor arterial vessels. After the target vessels were identified, the combined anticancer drugs were slowly injected after dilution with saline via catheter. Generally, two to three types were selected: cisplatin 60mg, adriamycin 40mg, mitomycin 10-14mg, Vp16 100-400mg, cyclophosphamide 0.5mg, and endansetron 8mg. After the operation, the tube was removed and pressure was applied to stop bleeding. After surgery, bed rest, observation of urination and lower limb activity, intravenous hydration, expansion with low-molecular dextrose, and the second treatment after 3 to 4 weeks. 2. Results The patients in this group were intubated up to 6 times, most of them were 2 to 4 times, the least was 1 time, and 5 cases were resected after interventional procedures. Judgment of efficacy: clinical symptoms were reduced, facial swelling gradually decreased, X-ray plain film and CT according to the recent standard of chemotherapy at home and abroad. Total remission was 21 cases, partial remission was 31 cases, no remission was 7 cases, and progression was 4 cases. The shortest survival time was 6 months and the longest was 4.5 years for simple perfusion, and one case is still alive at 4 years, and the proportion of those who survived 1 to 2 years is higher. The effect of central type multi-blood supply lung cancer is the best, and the lymph nodes in the hilum of the lung foci basically disappeared after two to three treatments, and the changes seemed normal on review. Five cases underwent surgical resection, including one case of undifferentiated carcinoma that was surgically resected after 3 times of infusion of anticancer drugs and survived 15 years of follow-up, achieving radical cure. one case survived 18 months, another two cases survived 4 years and 3 months, and one case survived 2 years. The histocytological observation was significant for squamous carcinoma, followed by adenocarcinoma. 2 cases of right upper peripheral type lung cancer showed no change after vascular perfusion. 3. Discussion 3.1 Treatment of mid- to late-stage lung cancer Comprehensive treatment, surgery, radiotherapy and chemotherapy should be selected according to the clinical symptoms, site, extent and histological classification of lung cancer. However, it is clinically found that about 2/3 of cases lose the opportunity of surgery, so choosing bronchial artery infusion chemotherapy is an important treatment for patients with inoperable lung cancer. Some scholars believe that surgery is preferred for primary lung cancer. According to the results of this group of cases, it is difficult to determine mediastinal lymph nodes and bloodstream metastases before surgery in some cases, and metastases are found intraoperatively, so preoperative transarterial instillation of anticancer drugs enhances the local drug concentration of tumor, improves the killing power of substantial tumor, makes tumor tissue shrink gradually, and provides new indications for preoperative resection. In addition, the efficacy of more instillations is better than that of less instillations, because the drugs can only enter the lung hilar and mediastinal lymphatic metastases, eliminate the proximal metastases of lung cancer and inhibit the further spread of tumor. However, the drug selection has a certain relationship with the efficacy and the number of instillations, vascular selection, methods, steps and individual differences. 3.2 Observation of the efficacy of tumor vessels The blood supply of bronchial lung cancer mainly comes from bronchial artery, followed by intercostal artery and internal mammary artery for blood supply, and selective insertion of target artery is the key to efficacy. If the tumor vessels are 2, they should be inserted and perfused separately. The number of blood supplying arteries and intercostal arteries directly affects the efficacy of tumor treatment. It is concluded that: those with more blood supply are better than those with less blood supply; central type is better than peripheral type; bronchial artery is better than intercostal artery. In this group, bronchial artery perfusion is the main blood supply, and in three cases, no blood supply artery was found. Horizontal perfusion via the bronchial bifurcation of the thoracic artery also achieved certain efficacy, but the efficacy was lower than that of the target vessel. 3.3 Observation of pathological tissue types According to the different tissue types, we select anti-cancer drugs with good efficacy, less adverse effects and lower toxicity. At present, the combination of drugs is used to enhance the efficacy, and the result is that the efficacy of squamous and undifferentiated carcinoma is better and the remission rate of adenocarcinoma is low. In this group, one case of right upper peripheral type lung cancer did not see tumor shrinkage after two times of intubation with different drugs, while the rest of cases had different degrees of shrinkage. The author believes that the principle of poor effect of adenocarcinoma is related to the large amount, small size, strong infiltration, low drug sensitivity and early hematogenous metastasis of adenocarcinoma, followed by insufficient amount of drugs to keep tumor cells uncontrolled. The poor effect is still being gradually explored. In conclusion, bronchial artery infusion of anticancer drugs is an effective method for treating lung cancer, but the quality of survival of this method and drug selection is also different, the recent efficacy is more accurate, and there is no uniform standard for medium and long term efficacy and survival time. Some scholars believe that surgery is the best method to treat lung cancer. The author believes that firstly, we should analyze the judgment and choose a reasonable treatment plan, and preoperative interventional therapy and regular postoperative chemotherapy plus adjuvant therapy with Chinese medicine can significantly improve the surgical resection rate and prolong the survival quality. Choosing multiple interventional treatments for inoperable lung cancer can prolong survival time, and choosing comprehensive treatment for bronchial lung cancer is appropriate.