To avoid serious hyperbilirubinemia, Lan Lan brought her baby to Dr. Zhang’s clinic for examination. Dr. Zhang suggested checking the child’s blood type, and the child’s blood type was “B”, and considering the possibility of hemolytic disease, he checked the full set of hemolysis, and the result was positive, which means that the baby’s jaundice was not ordinary physiological jaundice, but “ABO hemolytic disease”. Dr. Zhang patiently explained the disease to Lan Lan and her family. Hyperbilirubinemia is more common in the neonatal period and is characterized by jaundice, which usually appears early, with clinical sclera and skin yellowing, yellow stools and normal urine color. Elevated serum unconjugated bilirubin is the main feature. Clinically, it is mostly seen in neonatal hemolytic disease, cephalohematoma, erythrocytosis, breast milk jaundice, and infections. Maternal-infant ABO hemolytic disease: It refers to the mother-infant blood group incompatibility, and the mother’s blood group antibodies cause fetal and neonatal red blood cell destruction through the placenta, resulting in homozygous immune hemolytic disease. ABO blood group incompatibility (mother’s type O, child’s type A or B) is the most common, and can occur in the first child, with mild clinical symptoms, but occasionally serious. The mother’s blood type O, the child’s blood type A, B, AB, and/or positive prenatal screening for maternal antibodies; clinical basis of hemolysis: neonatal hyperbilirubinemia, decreased red blood cells, elevated reticulocytes, onset of the disease mostly early in life; confirming the diagnosis: Coombs’ test direct test +, and/or release test +, a positive free test alone must be accompanied by clinical Other hemolytic bases. Because ABO hemolytic disease is pathological jaundice, and the child’s jaundice is heavy, Lan Lan’s baby was hospitalized in Dr. Zhang’s ward, after careful treatment and care such as phototherapy, the child’s jaundice receded, 1 week later, the child recovered and went home, the family finally breathed a sigh of relief, Lan Lan hugged the baby and said emotionally, the next pregnancy and childbirth, also go to Dr. Zhang’s hospital, early examination, timely treatment, the child The baby is safe.