Most neonatal hemolytic anemias can be cured, but not all can be cured, such as congenital thalassemia and hereditary spherocytosis, which are more difficult to cure. The most common clinical hemolytic anemia in newborns is caused by blood group incompatibility, mostly ABO hemolysis, or hemolytic anemia caused by Rh blood group incompatibility. This type of anemia often occurs at the time of birth, so as long as the baby is given timely treatment at the time of birth, and in severe cases can be treated with blood exchange, usually can be cured, and will not occur again. Some newborns with hemolytic anemia are congenital diseases, such as congenital hereditary thalassemia, due to congenital genetic factors, clinically more difficult to cure, can be prevented through the causative factors, try to avoid the occurrence or aggravation of anemia. For hereditary spherocytosis, this type of hemolytic anemia can be active after the child reaches the age of 6 years for the treatment of splenectomy, usually can achieve the effect of alleviation, so that the anemia is corrected, jaundice disappeared, although not a cure, but the symptoms can be significantly relieved.