Bone marrow examination and cytochemical staining in hematology: including bone marrow aspiration smears and bone marrow biopsies, are of confirmatory value (e.g., leukemia, myeloma, myelofibrosis, etc.) and reference value (e.g., proliferative anemia) for certain hematologic disorders. Cytochemical stains are essential for the differential diagnosis of acute leukemia, such as peroxidase, alkaline phosphatase, and nonspecific esterase stains.
Splenectomy: Spleen excision removes the largest organ of the monocyte-macrophage system in the body, reducing the destruction and retention of blood cells and thus prolonging their lifespan. Splenectomy has definite efficacy in hemolytic anemia due to hereditary spherocytosis.