Recently, a patient with liver function impairment was admitted to our department, and the liver function test indicated that the transaminase level reached over 1000, which was really a shock. After asking about the medical history, we learned that the patient had been taking traditional Chinese medicine for many days, and only then did we understand the reason. Compared to western medicine, Chinese medicine has fewer toxic side effects, but its liver damage effects should not be ignored. In recent years, it has been reported that more than 1,000 cases of poisoning and more than 200 cases of death were caused by accidental ingestion, misuse or overdose of Chinese medicine. The pharmacogenic damage is mostly closely related to the route of administration, dose of medication and history of primary liver disease. (1) Chinese herbal medicines with liver-damaging effects: At present, Chinese herbal medicines with liver-damaging effects have been found or confirmed to include yellow herb seeds, cranberry, nongiri, kilim, pig shit bean, fish guts, four seasons of green, neem bark, guanzhong, lead, arsenic, grass wool, lei gong vine, five times seeds, neem, mulberry, kozi, clove, wild lily, sunflower seeds, hi tree, mugwort, earthly mustard, evergreen, shanglu, earthly panax notoginseng, wangnanzi, big maple seeds, etc. Most of them have the ability to clear heat and detoxify the liver. Most of them are herbs with heat-clearing and detoxifying effects, which are commonly used for sores, boils, eczema and tumors. These herbs are often used externally and have strong pharmacological activity. In terms of chemical composition, most of the herbs that cause liver damaging effects contain tannins, alkaloids and other components. Studies have shown that herbs containing hydrolyzed tannins are hepatotoxic, while those containing condensed tannins are less toxic. (2) The mechanism of liver damage of herbal medicines: ① Direct toxic effects, herbal medicines or their metabolites can interfere with cellular metabolism when they reach a certain concentration in the liver, which is characterized by high incidence, short latency period and dose dependence, such as Huang Yao Zi and Neem; ② Allergic reactions, although some drugs are not directly toxic, they can cause liver damage in susceptible individuals, which is characterized by low incidence, long latency period and no dependence on dose, such as (2) Allergic reactions, although some drugs are not directly toxic, can cause liver damage in susceptible individuals. (3) The pathological types of liver damage caused by Chinese medicine: ① hepatocyte damage, causing hepatocyte degeneration and necrosis, such as pig shit bean, fish gall bladder, Wang Jiang Nan Zi, Tu San Qi, etc. can cause this type of pathological damage; ② bile stagnation type, the pathological changes of bile duct bile embolism, or see cholangitis and mild hepatocyte necrosis, such as those caused by Guan Zong; ③ mixed type, such as those caused by Huang Yao Zi, both hepatocyte damage and bile stagnation. We would like to remind the general public that they should not take Chinese medicine indiscriminately in case of illness. This unscrupulous, lack of standards of the so-called “combined Chinese and Western medicine experts” really hate to the bone, but also our “false Chinese medicine culture” to express shame, the country’s sorrow.