Hepatitis B virus carriers who have recently felt tired need to consider hepatitis exacerbation, poor lifestyle habits that lead to excessive fatigue. In addition, it is also necessary to consider the factors of other diseases, such as anemia, hypothyroidism and so on. 1. Exacerbation of hepatitis B: when hepatitis B carriers have recently experienced symptoms of fatigue, it is recommended that liver function tests be conducted in a timely manner. Exacerbation of the disease will appear weakness, nausea and vomiting, anorexia, vague pain in the liver area, etc., which must be paid attention to, and timely access to medical care, improve liver function, liver ultrasound and other related examinations, and, if necessary, under the guidance of the doctor, carry out antiviral treatment, which can slow down the development of liver fibrosis and reduce the incidence of hepatocellular carcinoma. The development of liver fibrosis can be slowed down and the incidence of liver cancer can be reduced. 2. Bad life habits: patients who are hepatitis B carriers may have symptoms of fatigue if they have bad life habits such as exertion and staying up late, and the symptoms can be relieved after removing the triggers and taking sufficient rest. 3. Anemia: Hepatitis B patients due to liver damage, metabolic disorders in the body, sometimes anorexia, nausea and other symptoms, which will also affect the patient’s appetite, if the long-term poor appetite, may cause malnutrition anemia, may also appear symptoms of fatigue. 4. Hypothyroidism: patients with hypothyroidism are due to a variety of reasons leading to insufficient production of thyroid hormones, or the role of thyroid hormones is weakened, resulting in generalized hypometabolic syndrome, will also show symptoms of fatigue and tiredness and emotional apathy. Therefore, the causes of fatigue in hepatitis B carriers are very complex, and need to be combined with the patient’s accompanying symptoms to clarify the cause of the systematic treatment.