First of all, not all cases of slow gonorrhea require treatment. Some patients can be left untreated in the early stages of the disease and only require regular review. Only patients with indications for treatment, that is, those who have reached a certain stage of development that affects the patient’s work or life, or those who are developing rapidly, should be treated. This requires a thorough consideration by an experienced physician based on the patient’s overall condition. For patients with indications for treatment, the choice of treatment strategy needs to be considered in many ways, including the patient’s age, physical condition, the speed of disease progression and prognostic factors, and even the patient’s financial situation. In general, the main treatment for slow gonorrhea is chemotherapy, but of course, there are many kinds of chemotherapeutic drugs. Generally speaking, those with good effects (such as fludarabine) tend to have slightly greater side effects and are suitable for relatively young (under 70 years old) patients with good physical condition and fast disease progression; while for patients who are older, have poor physical condition or have other serious diseases in combination, or patients with slow disease progression and good prognosis, they can be treated with oral drugs such as tumor For older patients, patients with poor health or other serious diseases, or patients with slow disease progression and good prognosis, oral drugs such as tumorigenin can be used. In addition, immunotherapy represented by CD20 antibody has few side effects, and combined with chemotherapy can significantly improve the efficacy, but it is more expensive and not covered by medical insurance in most areas, so patients who have the conditions can apply it. There are also a few patients with very poor prognosis, especially with cytogenetic type 17p deletion, who should be considered for allogeneic HSCT if they are younger, have a donor, and also have indications for treatment. Therefore, the choice of treatment needs to be considered by an experienced physician taking into account a variety of circumstances.