The incidence of chronic gonorrhea in China is not as high as in Europe and the United States, and the age of patients at the onset of the disease is also older than in Europe and the United States, because the development of chronic gonorrhea is mostly slow, often with a survival period of more than 10 years, and it is difficult to be cured by chemotherapy, because chronic gonorrhea leukemia cells look similar to normal lymphocytes. (1) severe suppression of immune function; (2) expensive; and (3) more evidence is needed to determine whether survival is prolonged. Therefore, more conservative approaches such as a-interferon are often used in older patients. For younger patients younger than 50 years old, more intense chemotherapy regimens or even bone marrow transplantation are preferred to prolong life or even cure. I don’t know what kind of chemotherapy regimen you have used before, but now with 41,000 white blood cells and 91% lymphocytes, you are not in remission, so whether or not to undergo chemotherapy depends on whether the “damage” caused by “slow gonorrhea” is severe enough, or whether your goal is to prolong your survival or even cure. In the former case, progressive anemia and thrombocytopenia caused by “slow gonorrhea”, compression of normal organs by a mass that affects function, and recurrent infections are all indications for treatment. In the latter case, it depends on your wishes, but so far, chemotherapy alone cannot cure “slow gonorrhea”, but bone marrow transplantation can do so, but at a certain risk (transplant-related mortality rate of about 30%). If you are not in one of these situations, you can also choose to “wait and see” with conservative methods that have few side effects, such as a-interferon.