Chronic gonorrhea is a slow-progressing tumor and premature administration of drug therapy, especially chemotherapy, does not provide benefit to the patient, but can affect the quality of survival. Treatment should only be given if one of the following conditions is present: Indications for treatment: 1. Evidence of progressive bone marrow failure: manifested by a progressive decrease in hemoglobin and/or platelets. 2. 2. Giant spleen (e.g., >6 cm below the left costal margin) or progressive or symptomatic splenomegaly. 3, Giant lymph node enlargement (e.g., longest diameter >10 cm) or progressive or symptomatic lymph node enlargement. 4. Progressive lymphocytosis, such as 50% increase within 2 months, or lymphocyte doubling time (LDT) <6 months. When the initial lymphocyte <30×109/L, LDT alone cannot be used as an indication for treatment. 5. Lymphocyte count >200×109/L, or the presence of leukocyte stasis symptoms. 6, Autoimmune hemolytic anemia (AIHA) and/or thrombocytopenia (ITP) responding poorly to corticosteroids or other standard treatments. 7. The presence of less than one of the following disease-related symptoms: ① Weight loss ≥ 10% in the previous 6 months without apparent cause. ② Severe fatigue (e.g., ECOG physical status ≥ 2; inability to perform routine activities). ③No evidence of infection, body temperature >38.0°C for more than 2 weeks. ④No evidence of infection, night sweats for more than 1 month. 8, patient’s will.