Liver metastasis of pancreatic cancer in over 80 years old can improve the quality of life of patients and improve the prognosis of the disease through treatment options such as radiotherapy and targeted therapy. Liver metastasis in patients with pancreatic cancer in their 80s suggests that the disease has entered the advanced stage, and the prognosis is often poor. Due to the patient’s age, he cannot tolerate surgical treatment and interventional therapy, so he can improve his symptoms through comprehensive treatment such as radiotherapy and targeted therapy. The chemotherapeutic drugs that can be chosen include cisplatin and fluorouracil; targeted drugs include sunitinib and erlotinib. Due to individual differences, there is no absolute most effective drug, need to follow the doctor’s instructions to standardize the use, if there is an adverse reaction to consult a doctor in time, drug allergy is prohibited. By actively cooperating with doctors to receive standardized treatment, with a view to shrinking the tumor lesions, inhibiting tumor proliferation, relieving patients’ discomfort, improving the prognosis of the disease and prolonging the survival time of patients.