The correct order of medication for quadruple therapy is a proton pump inhibitor and bismuth before meals and an antibiotic after meals. Quadruple therapy refers to the eradication of Helicobacter pylori with four medications, which include a proton pump inhibitor, a bismuth agent and two antibiotics. 1. Proton pump inhibitor: Oral proton pump inhibitors, including pantoprazole, rabeprazole, omeprazole, esomeprazole, etc., are taken half an hour before meals. 2. Bismuth: take bismuth potassium citrate, colloidal bismuth pectin, and bismuth aluminate about half an hour before meal, commonly used drugs include bismuth potassium citrate, colloidal bismuth pectin, and bismuth aluminate compound. 3. Antibiotics: take antibiotics orally immediately after meals, commonly used antibiotics include clarithromycin, amoxicillin, metronidazole, furazolidone and so on. There is no special order required for the two antibiotics taken after meals. In addition, when taking quadruple drugs to treat Helicobacter pylori, you should avoid overeating, avoid spicy and irritating foods, and not stop and change drugs without authorization. Alcohol should be avoided when taking antibiotics such as furazolidone. The above drugs are prohibited for those who are allergic to them, and they should all be taken in accordance with medical advice. If the patient is diagnosed with Helicobacter pylori infection, it is recommended to go to the regular hospital in time, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.